Oxygen-based cues are direct assessments for a wide range of in vivo biological effects, ranging from mitochondrial disease to tissue engineering/regenerative medicine. This allows tuning the sensor for application at different conditions of temperature and humidity and therewith in different environments. Both temperature and humidity compensation were modeled using the finite-element method in good accordance with the experimental data. Adding silicone particles allows compensating the influence of humidity. To compensate for faster oxygen diffusion at higher temperatures, iron particles were added to the PVA matrix, resulting in a novel PVA/iron composite matrix. Since the oxygen diffusion coefficient in the PVA matrix strongly depends on temperature and humidity, two different approaches were developed within this work to compensate for these two effects. It can be used in packaging, sensors, and biotechnology applications. This sensor is based on a diffusion-controlled oxygen reaction of the indicator system methylene blue (MB)/leuco methylene blue (LMB) and riboflavin embedded in a water-loaded poly(vinyl alcohol) (PVA) matrix. In a previous work (Marek et al., 2013) a time-monitoring oxygen sensor was proposed.
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